Publications

Treatment of Head and Neck Cancer with Photodynamic Therapy with Redaporfin: A Clinical Case Report

Santos L, L, Oliveira J, Monteiro E, Santos J, Sarmento C

Case Rep Oncol 2018;11:769-776

A first in human study using photodynamic therapy with Redaporfin in advanced head and neck cancer

Julio Oliveira, Eurico Monteiro, Juliana Santos, Jose Dinis Silva, Luis Almeida, Lúcio Lara Santos

J Clin Oncol 35, 2017 (suppl; abstr e14056)

Ultrafast Dynamics of Manganese(III), Manganese(II), and Free-Base Bacteriochlorin: Is There Time for Photochemistry?

Fabio A. Schaberle, Artur R. Abreu, Nuno P. F. Gonçalves, Gonçalo F. F. Sá, Mariette M. Pereira, and Luís G. Arnaut

Inorg. Chem., 2017, 56 (5), pp 2677–2689.

Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers

Dabrowski JM, Pucelik B, Regiel-Futyra A, Brindell M, Mazuryk O, Kyziol A, Stochel G, Macyk W, Arnaut LG

Coordination Chemistry Reviews, Volume 325, 15 October 2016, Pages 67-101, ISSN 0010-8545.

Pro-oxidant and antioxidant effects in photodynamic therapy: cells recognise that not all exogenous ROS are alike

Soares HT, Campos JRS, Gomes-da-Silva LC, Schaberle FA, Dabrowski JM, Arnaut LG

Chembiochem. 2016 May 3; 17(9):836-42. doi: 10.1002/cbic.201500573.

Intravenous single-dose toxicity of redaporfin-based photodynamic therapy in rodents

Rocha LB, Schaberle FA, Dabrowski JM, Simões S, Arnaut LG

Int J Mol Sci. 2015 Dec 8; 16(12):29236-49. doi: 10.3390/ijms161226162.

Photodynamic therapy (PDT) of cancer: from local to systemic treatment

Dabrowski JM, Arnaut LG

Photochem Photobiol Sci. 2015 Oct; 14(10):1765-80. doi: 10.1039/c5pp00132c.

Synthesis and characterization of biocompatible bimodal meso-sulfonamide-perfluorophenylporphyrins

Vinagreiro C, Gonçalves NPF, Calvete MJF, Schaberle FA, Arnaut LG, Pereira MM

Journal of Fluorine Chemistry, Volume 180, December 2015, Pages 161-167, ISSN 0022-1139.

Towards tuning PDT relevant photosensitizer properties: comparative study for the free and Zn2+ coordinated meso-tetrakis[2,6-difluoro-5-N-methylsulfamylo)phenyl]porphyrin

Dabrowski J, Pucelik B, Pereira MM, Arnaut LG, Stochel G

Journal Of Coordination Chemistry. Vol. 68 , Iss. 17-18,2015.

Elimination of primary tumours and control of metastasis with rationally designed bacteriochlorin photodynamic therapy regimens

Rocha LB, Gomes-da-Silva LC, Dabrowski JM, Arnaut LG

Eur J Cancer. 2015 Sep; 51(13):1822-30. doi: 10.1016/j.ejca.2015.06.002.

The role of strong hypoxia in tumors after treatment in the outcome of bacteriochlorin-based photodynamic therapy

Krzykawska-Serda M, Dabrowski JM, Arnaut LG, Szczygiel M, Urbanska K, Stochel G, Elas M

Free Radic Biol Med. 2014 Aug; 73:239-51. doi: 10.1016/j.freeradbiomed.2014.05.003.

Modulation of biodistribution, pharmacokinetics, and photosensitivity with the delivery vehicle of a bacteriochlorin photosensitizer for photodynamic therapy

Saavedra R, Rocha LB, Dabrowski JM, Arnaut LG

ChemMedChem. 2014 Feb; 9(2):390-8. doi: 10.1002/cmdc.201300449.

Photodynamic therapy efficacy enhanced by dynamics: the role of charge transfer and photostability in the selection of photosensitizers

Arnaut LG, Pereira MM, Dabrowski JM, Silva EF, Schaberle FA, Abreu AR, Rocha LR, Barsan MM, Urbanska K, Stochel G, Brett CM

Chemistry. 2014 Apr 25; 20(18):5346-57. doi: 10.1002/chem.201304202.

Synthesis of binaphthyl based phosphine and phosphite ligands

Pereira MM, Calvete MJF, Carrilho RMB, Abreu AR

Chem. Commun., 2015,51, 8070-8073. doi: 10.1039/C3CS60116A.

The challenging combination of intense fluorescence and high singlet oxygen quantum yield in photostable chlorins – A contribution to theranostics

Silva EFF, Schaberle FA, Monteiro CJP, Dabrowski JM, Arnaut L

Photochem. Photobiol. Sci., 2013, 12, 1187-1192. doi: 10.1039/C3PP25419D.

From elementary reactions to chemical relevance in the photodynamic therapy of cancer

Arnaut LG, Formosinho SJ

Pure and Applied Chemistry, 85.7 (2013): 1389-1403. doi: 10.1351/PAC-CON-12-08-16

Synthesis of chiral bis-MOP-type diphosphines. Chelating effect in nickel-catalyzed phosphination

Abreu AR, Peixoto AF, Almeida AR, Lourenço MA, Neves ACB, Bayón JC, Pereira MM

Chemical Letters. Vol. 42 (2013) No. 1 P 37-39

Synergistic Effects of Singlet Oxygen and Hydroxyl Radical in Photodynamic Therapy and Antitumor Immunity with Photostable Sulfonamide Bacteriochlorins.

Dabrowski JM, Silva E, Krzykawski M, Rocha L, Urbanska K, Pereira MM, Stochel G, Arnaut LG.

Free Radical Biology and Medicine, Volume 53, Supplement 2, 1 November 2012, Page S18, ISSN 0891-5849.

Amphiphilic meso(sulfonate ester fluoroaryl)porphyrins: refining the substituents of porphyrin derivatives for phototherapy and diagnostics.

Simões AVC, Adamowicz A, Dabrowski JM, Calvete MJF, Abreu AR, Stochel G, Arnaut LG, Pereira MM.

Tetrahedron, Volume 68, Issue 42, 21 October 2012, Pages 8767-8772, ISSN 0040-4020.

On the singlet states of porphyrins, chlorins and bacteriochlorins and their ability to harvest red/infrared light.

Monteiro CJP, Pina J, Pereira MM, Arnaut LG.

Photochem Photobiol Sci. 2012 Jul; 11(7):1233-8. doi: 10.1039/c2pp25021g.

Combined effects of singlet oxygen and hydroxyl radical in photodynamic therapy with photostable bacteriochlorins: Evidence from intracellular fluorescence and increased photodynamic efficacy in vitro.

Dabrowski JM, Arnaut LG, Pereira MM, Urbanska K, Simoes S, Stochel G, Cortes L.

Free Radic Biol Med. 2012 Apr 1; 52(7):1188-200. doi: 10.1016/j.freeradbiomed.2011.12.027.

An insight into solvent-free diimide porphyrin reduction: a versatile approach for meso-aryl hydroporphyrin synthesis.

Pereira MM, Abreu AR, Goncalves NPF, Calvete MJF, Simoes AVC, Monteiro CJP, Arnaut LG, Eusebio ME, Canotilho J.

Green Chem., 2012,14, 1666-1672. doi: 10.1039/C2GC35126A

Separation and atropisomer isolation of ortho-halogenated tetraarylporphyrins by HPLC. Full characterization using 1D and 2D NMR.

Monteiro CJP, Pereira MM, Goncalves NPF, Carvalho CG, Neves ACB, Abreu AR, Arnaut LG, Silva AMS.

Journal of Porphyrins and Phthalocyanines. 2012 16:03, 316-323

Unsymmetrical porphyrins: the role of meso-substituents on their physical properties.

Henriques CA, Goncalves NPF, Abreu AR, Calvete MJF, Pereira MM.

Journal of Porphyrins and Phthalocyanines. 2012 16:03, 290-296

Improved biodistribution, pharmacokinetics and photodynamic efficacy using a new photostable sulfonamide bacteriochlorin.

Dabrowski JM, Arnaut LG, Pereira MM, Urbanska K, Stochel G.

Med. Chem. Commun., 2012, 3, 502-505. doi: 10.1039/C2MD00308B

Rhodium/tris-binaphthyl chiral monophosphite complexes: Efficient catalysts for the hydroformylation of disubstituted aryl olefins.

Carrilho RMB, Neves ACB, Lourenco MAO, Abreu AR, Rosado MTS, Abreu PE, Eusebio ME, Kollar L, Bayon JC, Pereira MM.

Journal of Organometallic Chemistry, Volume 698, 1 February 2012, Pages 28-34, ISSN 0022-328X.

New halogenated water-soluble chlorin and bacteriochlorin as photostable PDT sensitizers: synthesis, spectroscopy, photophysics, and in vitro photosensitizing efficacy

Dabrowski JM, Arnaut LG, Pereira MM, Monteiro CJ, Urbanska K, Simões S, Stochel G.

ChemMedChem. 2010 Oct 4; 5(10):1770-80. doi: 10.1002/cmdc.201000223.

Mechanisms of singlet-oxygen and superoxide-ion generation by porphyrins and bacteriochlorins and their implications in photodynamic therapy

Silva EF, Serpa C, Dabrowski JM, Monteiro CJ, Formosinho SJ, Stochel G, Urbanska K, Simões S, Pereira MM, Arnaut LG

Chemistry. 2010 Aug 9; 16(30):9273-86. doi: 10.1002/chem.201000111.

Synthesis and Photophysical Properties of Amphiphilc Halogenated Bacteriochlorins: New Opportunities for Photodynamic Therapy of Cancer

Pereira MM, Monteiro CJP, Simões AVC, Pinto SMA, Arnaut LG, Sá GFF, Silva EFF, Rocha LB, Simões S., Formosinho SJ

Journal of Porphyrins and Phthalocyanines. 2009 13:04n05, 567-573

Synthesis of amphiphilic sulfonamide halogenated porphyrins: MALDI-TOFMS characterization and evaluation of 1-octanol/water partition coefficients

Monteiro CJP, Pereira MM, Pinto SMA, Simões AVC, Sá GFF, Arnaut LG, Formosinho SJ, Simões S and Wyatt MF

Tetrahedron, Volume 64, Issue 22, 26 May 2008, Pages 5132-5138, ISSN 0040-4020.

Synthesis, photophysical studies and anticancer activity of a new halogenated water-soluble porphyrin

Dabrowski JM, Pereira MM, Arnaut LG, Monteiro CJ, Peixoto AF, Karocki A, Urba?ska K, Stochel G.

Photochem Photobiol. 2007 Jul-Aug; 83(4):897-903.

Spectroscopic properties and photodynamic effects of new lipophilic porphyrin derivatives: efficacy, localisation and cell death pathways

Kramer-Marek G, Serpa C, Szurko A, Widel M, Sochanik A, Snietura M, Kus P, Nunes RM, Arnaut LG, Ratuszna A.

J Photochem Photobiol B. 2006 Jul 3; 84(1):1-14.

A comparative study of water soluble 5,10,15,20-tetrakis(2,6-dichloro-3-sulfophenyl) porphyrin and its metal complexes as efficient sensitizers for photodegradation of phenols

Monteiro CJ, Pereira MM, Azenha ME, Burrows HD, Serpa C, Arnaut LG, Tapia MJ, Sarakha M, Wong-Wah-Chung P, Navaratnam S.

Photochem Photobiol Sci. 2005 Aug; 4(8):617-24.

Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma

Drzewiecka A, Urbanska K, Matuszak Z, Pineiro M, Arnaut LG, Habdas J, Ratuszna A, Stochel G.

Acta Biochim Pol. 2001; 48(1):277-82.